东北农业大学向文胜教授论文一字不改照抄别人论文引言

方老师:

你好!东北农业大学向文胜教授论文抄袭。introduction部分一字不改的抄袭上海交通大学发表的论文。这样的教授居然评为杰青,今年还参评国家科技奖。

Role of nsdA in negative regulation of antibiotic production andmorphological differentiation in Streptomyces bingchengensis.J Antibiot (Tokyo). 2009; 62(6):309-13 (ISSN: 0021-8820)Wang XJ; Guo SL; Guo WQ; Xi D; Xiang WSSchool of Life Science, Northeast Agricultural University, Harbin,China.

Pathway-specific regulatory genes, such as actII-orf4, redD, cdaR andmmyR, are at the bottom of the regulatory network, each controllingone antibiotic biosynthetic pathway.3 Global regulators, such asbldA,4 bldB,5 bldD6 and bldG,7 perform the highest level regulationand affect both morphological and physiological differentiation.8, 9At intermediate levels in the regulatory cascades, many regulatorygenes, such as afsB,10 abaA,11 absB,12 afsK-afsR13, 14 and tcrA,15 andtwo-component systems, such as afsQ1-afsQ2,16 absA1-absA2,17, 18cutS-cutR19 and phoR-phoP,20 have been identified, which regulate thesynthesis of two or more antibiotics. absA1-absA2, cutS-cutR, phoR-phoP,tcrA and some pathway-specific repressors regulate antibioticproduction in a negative manner, as mutations in these genes resultedin the overproduction of the corresponding antibiotic(s). Globalregulators may also play a negative role, as in the case of theA-factor receptor protein, ArpA, in Streptomyces griseus. WhenA-factor is absent, ArpA binds to the adpA promoter and represses theexpression of AdpA, which is an activator of a regulon that consistsof operons involved in mycelial differentiation and antibioticproduction. The arpA-null mutants produced more streptomycin andformed aerial hyphae earlier than the wild-type strain did.21, 22, 23Recent microarray data have indicated a cross-regulation amongdisparate antibiotic biosynthetic pathways and even somebackregulation from cluster-situated regulators to a “higher level”pleiotropic regulatory gene.24The identification of new genes that regulate antibiotic biosynthesisand mycelial differentiation is important for understanding thefactors affecting antibiotic yield. In this study, we report theidentification of a new gene, nsdA, negatively affecting both processes.

Identification of a Gene Negatively Affecting Antibiotic Productionand Morphological Differentiation in Streptomyces coelicolor A3(2)?Wencheng Li,1 Xin Ying,1 Yuzheng Guo,1 Zhen Yu,1 Xiufen Zhou,1,2 ZixinDeng,1,2 Helen Kieser,3 Keith F. Chater,3 andMeifeng Tao1,*J Bacteriol. 2006 Dec; 188(24): 8368C8375.Published online 2006 Oct 13. doi: 10.1128/JB.00933-06PMCID: PMC1698255

Pathway-specific regulatory genes, such as actII-orf4, redD, cdaR, andmmyR, are at the bottom of the regulatory network, each controllingone antibiotic biosynthetic pathway (4). Global regulators, such asbldA (16), bldB (14), bldD (15), and bldG (5), perform thehighest-level regulation and affect both morphological andphysiological differentiation (9, 10). At intermediate levels in theregulatory cascades, many regulatory genes, such as afsB (22), abaA(17), absB (7), afsK-afsR (21, 36), and tcrA (33), and two-componentsystems, such as afsQ1-afsQ2 (26), absA1-absA2 (1, 42), cutS-cutR (8),and phoR-phoP (44), have been identified that regulate the synthesisof two or more antibiotics. absA1-absA2, cutS-cutR, phoR-phoP, andtcrA and some pathway-specific repressors regulate antibioticproduction in a negative way, since null mutations in these genesresulted in the overproduction of the corresponding antibiotic(s).Global regulators may also play a negative role, as in the case of theA-factor receptor protein ArpA in Streptomyces griseus. When A-factoris absent, ArpA binds to the adpA promoter and represses theexpression of AdpA, which is an activator of a regulon that consistsof operons involved in mycelial differentiation and antibioticproduction. arpA-null mutants produced more streptomycin and formedaerial hyphae earlier than did the wild-type strain (39). Recentmicroarray data have indicated a cross-regulation among disparateantibiotic biosynthetic pathways and even some back regulation fromcluster-situated regulators to a “higher level” pleiotropicregulatory gene (23).The identification of new genes that regulate antibiotic biosynthesisand mycelial differentiation is important for understanding thefactors affecting antibiotic yield. In this study, we report theidentification of a new gene negatively affecting both processes.

(XYS20150328)

This site is supported by ebookdiy.com.

Be the first to comment

Leave a Reply